The Norwegian origin.
DISCUSSION:
THE NORWEGIAN ORIGIN:
SURVIVING THE PLAGUES: DISCUSSION: THE CARRIER OF EACH OF THE FOUR MUTATIONS TODAY ARE DECENDANTS OF ONE OR A FEW INDIVIDUALS SURVIVING THE PLAGUES.
The findings of this study meet our hypothesis that the uneven regional distribution of Breast - Ovarian cancer kindreds in the Norwegian population is due to the presence of founder mutation.
We conclude that the great majority of today"s estimated 4000 BRCA 1 mutation carriers are decendants of a small nuber of (possibly as few as four) survivors of the medieval Bubonic plagues 600 years ago.
We have made no attemps to estimate the ages of these mutations.
They may have been present before the plagues,since the combined probability that four new mutations have ocurred and expanded in the liited population shortly after the plagues seems low.
We can only speculate that these founder mutations are of Norwegian origin.
The 1135insA mutation has been reported a handful number of times from Continental Europe, and around 10 times from the Us(22), compared with 30 identified Norwegian 1135insA families.
This mutation may have migrated from Northern to Central Europe during medieval or more recent inland trading journeys or conversely, been ibtroduced by early settlers and enriched in the agri cultural areas of Norway.
These figures are also compatible with the recent cross - Atlantic emigration of around one million Norwegians, of whom a large number came from the South - West, and with the relative occurrence of the mutations in Norway and in North America.
The 816delGt wad foud in 16 Norwegian and three US families , 3347delAG in 17 Norwegian and three US families and 1675delIA in 37 Norwegian and 11 US families( as well as two Swedish families ).
Forøvrig:
Se arkiv.
Drevet av Rendalen Historie