The three founders - F1, F2, F3.
THE THREE FOUNDERS(F1, F2, F3), THEIR IMMEDIATE DESCENDANTS AND THE DIAGNOSTIC HYPOTHESES.
F1:
HISTORICAL INFORMATION.
F1 is the oldest of the three founders. He was of Pomeranian descent, He was born some time between 1592 and 1622, when his German - born father was a protestant vicar in a neigbouring community(44).
F1 was married and had only one son born in 1656(11). Later, his son became the sheriff of the lokal community. F1 became insane and deposed in 1661(11).
His great grandson also became insane. F1 was insane(10), but lived in the lokal community with his wife and their 9 - year - old son in 1665 (Figs 1 - 5).
He died there in 1676 (11).
CLINICAL CONSIDERATIONS.
F1 must have become psychotic at a mature age, which makes schizophrenia to appear as an unlikely diagnosis.
Contributory factors to this exclusion diagnosis are the fact that he was educated and married and had a son before the onset of his disease.
F1 must have had some standing in the local community.
His son became the local sheriff and probably inherited his standing in the community.
THE DIAGNOSTIC HYPOTHESIS: Other non - organic psychosis.
F2:
HISTORICAL INFORMATION.
F2 was a local farmer. He was born in 1692(11). He was married and had 10 children of whom only one grew up to have a family his own. The other nine died, some as small children and others as young unmarried adults. One of his unmarried daughters died in a catatonic spell at 30 years of age. His brother killed his fiancee.
He was sentenced to death but evaded justice by fleeing to Sweden(11).
A Great grandson of F2 was arrested for vagrancy and a few named descendants of F2 were according to both local genealogies(11) and national population censuses of the 19th century(13 - 15), either categorized as insane, incapacitated or illiterate.
F2 himself was brought to court at 32 years of age for deviant behaviour(11).
CLINICAL CONSIDERATIONS:
F2 was brought to court at an early ages and must have been a poor caretager. We have no direct information of psychosis in his case. One of his daugthers probably died of catatonia and other descendants of the 19te century were characterized as insane. The behaveior of F2 reflect cognitive failures, behavioural disturbances and psychosocial incompetence, which is the very historical definition of the diagnosis of dementia(19) which preceded the term of dementia praecox.
Similar behaviour was not displayed in any of their ancestors in the 1665 population( 11 - 15).
THE DIAGNOSTIC HYPOTHESIS:
Szhizophrenia spectrum disorder.
F3:
HISTORICAL INFORMATION.
F3 was son of a clergyman. He was born in 1723 and died in a fire with his 90 - years old mother in 1767(11).
His mother was a well-to-do women of English descent. Her great grandfather migrated to Trondheim, Norway, from Yorkshire in the 16th century (45). F2 married a local girl the very year before his violent death.
He had one daughter born in 1766. His mothers aunt committed suicide in a spell of madness in 1680 (45). F2 himself was characterized as "less worthy" (11).
CLINICAL CONSIDERATIONS:
F3 came from a wealthy family. All his siblings did well in life. Characterized as "less worthy" , he stayed with his mother and married late.
A family history of suicide and insanity raises the question of an extended suicide in the case of the violent death of F3 and his mother; although an accident cannot be ruled out.
THE DIAGNOSTIC HYPOTHESIS:
Depressive episode and suicide.
RENDALEN 1877 - 2005.
NIFU MERITTERED.
PART 1.
PART 2.
HOSPITAL - TREATED PSYCHOSIS AND SUICIDE:
Genetic founder effects.
OBJECTIVE:
To demonstrate the existence of genetic founder effects in - Treated cases of psychosis and - self harm in historical cohorts of a smal rural population.
METHOD:
These cohorts consist of named persons born after 1845.
The cumulative case registers were linked to the purported pedigrees of three presumed mentally ill founders living in the community in the community in the 17th and 18th centuries.
We compared the incidence of psychosis and self harm in the genitally unexposed population and in three exposed founder population.
RESULTS:
We found a preponderance of organic mental disorder and schizoprenia in the twice - exposed founder population and of non - organic psychosis and self harm in the thrice - exposed founder population.
CONCLUSION:
The genetic impact of the founders seems to have affected the incidence rates at severe psyhiatric disorders of their decendants in two ways.
A founder effect is detected in organic mental disorder and schizoprenia, and it seems to run independently of that detected in affective psychotic disorder and intentional self - harm.
SIGNIFICANT OUTCOMES:
1.
Genetic foundereffects of psychotic disorder and suicide have been found.
2.
A genetic based dichotomy is found in psychotic disorder along cognitive and affective lines.
3.
Some genetic constelations appear to protect against certain mental disorder.
NORGES BIDRAG TIL "ACTA PSYCHIATRICA SCANDINAVIA".
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Drevet av Rendalen Historie